| Week of 5/15 |
| Defensor Sporting 0 Cerro Porteno 1 |
| 7:15 PM Tue | 100.0* | Lottery seed |
| Gremio | +0.5 | |
| Cerro Porteno | -5.1 | |
| Defensor Sporting | +5.0 | |
|
| Flamengo 2 Emelec 0 |
| 9:45 PM Wed | 100.0* | Lottery seed |
| River Plate | +0.9 | |
| Flamengo | -4.7 | |
| Emelec | +2.9 | |
|
| Colo-Colo 2 Bolivar 0 |
| 9:30 PM Tue | 100.0* | Lottery seed |
| Colo-Colo | -6.0 | |
| Bolivar | +5.0 | |
|
| Deportivo Lara 2 Corinthians 7 |
| 9:30 PM Thu | 100.0* | Lottery seed |
| Corinthians | -5.4 | |
| Deportivo Lara | +4.8 | |
|
| Delfin 1 Atletico Nacional 0 |
| 7:15 PM Tue | 100.0* | Lottery seed |
| Atletico Nacional | +3.0 | |
| Delfin | -5.2 | |
|
| Monagas 1 Gremio 2 |
| 9:30 PM Tue | 100.0* | Lottery seed |
| Gremio | -3.8 | |
| Cerro Porteno | +0.7 | |
| Monagas | +3.9 | |
|
| Boca Juniors 5 Alianza Lima 0 |
| 9:45 PM Wed | 100.0* | Lottery seed |
| Boca Juniors | -4.6 | |
| Junior Barranquilla | +1.3 | |
| Alianza Lima | +1.3 | |
|
| Penarol 2 The Strongest 0 |
| 7:15 PM Thu | 100.0* | Lottery seed |
| Atletico Tucuman | +0.7 | |
| Penarol | -4.4 | |
| Junior Barranquilla | +0.4 | |
| The Strongest | +2.5 | |
|
| Palmeiras 3 Junior Barranquilla 1 |
| 9:45 PM Wed | 100.0* | Lottery seed |
| Palmeiras | -1.0 | |
| Boca Juniors | -1.4 | |
| Junior Barranquilla | +3.8 | |
|
| Libertad 0 Atletico Tucuman 0 |
| 7:15 PM Thu | 100.0* | Lottery seed |
| Libertad | -1.3 | |
| Atletico Tucuman | +0.6 | |
| Penarol | +0.6 | |
|
| Millonarios 1 Independiente 1 |
| 9:30 PM Thu | 100.0* | Lottery seed |
| Independiente | +0.4 | |
| Millonarios | +1.2 | |
|
| Week of 5/22 |
| Estudiantes 3 Nacional 1 |
| 7:15 PM Thu | 100.0* | Lottery seed |
| Santos | -2.1 | |
| Estudiantes | -5.0 | |
| Nacional | +5.7 | |
| Santa Fe | +0.6 | |
| Junior Barranquilla | +0.6 | |
|
| Gremio 1 Defensor Sporting 0 |
| 7:15 PM Wed | 100.0* | Lottery seed |
| Gremio | -3.2 | |
| Libertad | +0.5 | |
| Cerro Porteno | +1.4 | |
| Junior Barranquilla | -0.4 | |
| Vasco da Gama | -0.6 | |
| Universidad de Chile | -0.6 | |
| Defensor Sporting | +4.3 | |
|
| Independiente 2 Deportivo Lara 0 |
| 9:30 PM Thu | 100.0* | Lottery seed |
| Corinthians | +0.9 | |
| Independiente | -6.2 | |
| Boca Juniors | +0.6 | |
| Millonarios | +0.2 | |
| Real Garcilaso | -0.6 | |
| Deportivo Lara | +4.1 | |
|
| Bolivar 2 Delfin 1 |
| 9:30 PM Thu | 100.0* | Lottery seed |
| Atletico Nacional | -0.6 | |
| Boca Juniors | -0.3 | |
| Colo-Colo | -0.2 | |
| Bolivar | -4.9 | |
| Delfin | +5.4 | |
| Real Garcilaso | +0.4 | |
|
| Cerro Porteno 3 Monagas 2 |
| 7:15 PM Wed | 100.0* | Lottery seed |
| Gremio | +1.4 | |
| Cerro Porteno | -3.8 | |
| Atletico Tucuman | +0.4 | |
| Vasco da Gama | -0.4 | |
| Universidad de Chile | -0.4 | |
| Monagas | +2.8 | |
|
| Corinthians 0 Millonarios 1 |
| 9:30 PM Thu | 100.0* | Lottery seed |
| Libertad | -0.4 | |
| River Plate | -0.4 | |
| Cruzeiro | -0.4 | |
| Corinthians | +2.8 | |
| Millonarios | -4.3 | |
| Santa Fe | +0.6 | |
| Junior Barranquilla | +0.6 | |
| Real Garcilaso | +0.4 | |
|
| Cruzeiro 2 Racing 1 |
| 9:30 PM Tue | 100.0* | Lottery seed |
| Libertad | -0.4 | |
| Cruzeiro | -5.3 | |
| Racing | +3.8 | |
| Atletico Tucuman | +0.6 | |
| Boca Juniors | +0.4 | |
|
| Emelec 0 Santa Fe 3 |
| 9:45 PM Wed | 100.0* | Lottery seed |
| Santa Fe | -4.4 | |
| Junior Barranquilla | +0.6 | |
| Vasco da Gama | +0.4 | |
| Universidad de Chile | +0.4 | |
| Monagas | -0.4 | |
| The Strongest | -0.4 | |
| Emelec | +1.6 | |
|
| Universidad de Chile 0 Vasco da Gama 2 |
| 9:30 PM Tue | 100.0* | Lottery seed |
| Junior Barranquilla | -0.4 | |
| Vasco da Gama | -2.9 | |
| Universidad de Chile | +3.9 | |
| The Strongest | +0.4 | |
|
| Atletico Nacional 0 Colo-Colo 0 |
| 9:30 PM Thu | 100.0* | Lottery seed |
| River Plate | -0.4 | |
| Cruzeiro | -0.4 | |
| Atletico Nacional | -2.1 | |
| Colo-Colo | +2.7 | |
| Santa Fe | +0.4 | |
|
| Santos 0 Real Garcilaso 0 |
| 7:15 PM Thu | 100.0* | Lottery seed |
| River Plate | -0.4 | |
| Cruzeiro | -0.3 | |
| Santos | +0.8 | |
| Nacional | -0.0 | |
| Santa Fe | -0.4 | |
| Junior Barranquilla | -0.4 | |
| Real Garcilaso | +0.9 | |
|
| River Plate 0 Flamengo 0 |
| 9:45 PM Wed | 100.0* | Lottery seed |
| Libertad | -0.4 | |
| River Plate | -1.4 | |
| Flamengo | +1.4 | |
| Atletico Tucuman | +0.4 | |
| Boca Juniors | +0.4 | |