| Week of 5/16 |
| San Lorenzo 2 Flamengo 1 |
| 9:45 PM Wed | 100.0* | Lottery seed |
| San Lorenzo | -8.7 | |
| Flamengo | +7.9 | |
|
| Universidad Catolica 2 Atletico-PR 3 |
| 9:45 PM Wed | 100.0* | Lottery seed |
| San Lorenzo | +0.7 | |
| Atletico-PR | -6.0 | |
| Flamengo | +1.2 | |
| Libertad | -0.6 | |
| Universidad Catolica | +4.7 | |
|
| Independiente Medellin 1 Emelec 2 |
| 11:15 PM Tue | 100.0* | Lottery seed |
| River Plate | -0.5 | |
| Emelec | -5.3 | |
| Independiente Medellin | +5.3 | |
|
| Botafogo 1 Atletico Nacional 0 |
| 9:45 PM Thu | 100.0* | Lottery seed |
| Botafogo | -4.6 | |
| Barcelona | +1.0 | |
| Atletico Nacional | +3.3 | |
| Libertad | -0.3 | |
| Universidad Catolica | -0.3 | |
|
| Lanus 3 Chapecoense 0 |
| 9:45 PM Wed | 100.0* | Lottery seed |
| Lanus | -4.3 | |
| Chapecoense | +4.3 | |
| Libertad | -0.2 | |
|
| Sporting Cristal 0 Santa Fe 2 |
| 7:30 PM Wed | 100.0* | Lottery seed |
| Santos | +0.2 | |
| The Strongest | +0.7 | |
| Santa Fe | -5.0 | |
| Sporting Cristal | +3.2 | |
|
| Atletico-MG 4 Godoy Cruz 1 |
| 9:45 PM Tue | 100.0* | Lottery seed |
| Atletico-MG | -5.4 | |
| Godoy Cruz | +4.5 | |
|
| Barcelona 0 Estudiantes 3 |
| 7:30 PM Thu | 100.0* | Lottery seed |
| Botafogo | -0.4 | |
| Barcelona | +2.7 | |
| Estudiantes | -3.6 | |
| Atletico Nacional | +0.4 | |
| Libertad | +0.3 | |
| Universidad Catolica | +0.4 | |
|
| Melgar 2 River Plate 3 |
| 9:00 PM Thu | 100.0* | Lottery seed |
| Atletico-MG | +0.3 | |
| River Plate | -2.1 | |
| Emelec | -0.4 | |
| Independiente Medellin | -0.6 | |
| Melgar | +3.5 | |
|
| Libertad 1 Sport Boys 1 |
| 9:45 PM Tue | 100.0* | Lottery seed |
| Libertad | +1.4 | |
| Sport Boys | +0.8 | |
|
| Zulia 0 Nacional 0 |
| 7:30 PM Tue | 100.0* | Lottery seed |
| Zulia | +1.5 | |
|
| The Strongest 1 Santos 1 |
| 7:30 PM Wed | 100.0* | Lottery seed |
| Santos | +0.1 | |
| The Strongest | +0.6 | |
|
| Week of 5/24 |
| Penarol 2 Jorge Wilstermann 0 |
| 9:45 PM Wed | 100.0* | Lottery seed |
| Palmeiras | -1.4 | |
| Atletico-PR | -0.5 | |
| Jorge Wilstermann | +4.9 | |
| Atletico Tucuman | -0.8 | |
| Libertad | +0.4 | |
| Penarol | -2.9 | |
| Universidad Catolica | +0.6 | |
| Zulia | +0.6 | |
|
| River Plate 1 Independiente Medellin 2 |
| 7:30 PM Thu | 100.0* | Lottery seed |
| Atletico-MG | -0.6 | |
| Lanus | -0.6 | |
| River Plate | +2.4 | |
| Palmeiras | -0.5 | |
| Emelec | +1.5 | |
| Independiente Medellin | -4.5 | |
| Atletico Tucuman | +0.3 | |
| Chapecoense | +0.3 | |
| Libertad | +0.3 | |
| Penarol | +0.3 | |
|
| Emelec 3 Melgar 0 |
| 7:30 PM Thu | 100.0* | Lottery seed |
| Emelec | -4.8 | |
| Atletico-PR | +0.6 | |
| The Strongest | +0.5 | |
| Jorge Wilstermann | +0.4 | |
| Independiente Medellin | +1.3 | |
| Atletico Nacional | -0.3 | |
| Libertad | -0.3 | |
| Penarol | -0.4 | |
| Universidad Catolica | -0.4 | |
| Zulia | -0.4 | |
| Melgar | +2.2 | |
|
| Palmeiras 3 Atletico Tucuman 1 |
| 9:45 PM Wed | 100.0* | Lottery seed |
| Palmeiras | -5.2 | |
| Santos | +0.4 | |
| Jorge Wilstermann | +0.4 | |
| Santa Fe | -0.4 | |
| Atletico Tucuman | +4.7 | |
|
| Atletico Nacional 3 Barcelona 1 |
| 9:45 PM Thu | 100.0* | Lottery seed |
| Botafogo | -1.2 | |
| Barcelona | +3.2 | |
| Atletico Nacional | -3.4 | |
| Libertad | +0.6 | |
| Penarol | +0.6 | |
| Universidad Catolica | +0.6 | |
| Zulia | +0.6 | |
|
| Estudiantes 1 Botafogo 0 |
| 9:45 PM Thu | 100.0* | Lottery seed |
| Botafogo | +3.2 | |
| Barcelona | -1.2 | |
| Estudiantes | -3.2 | |
| Santa Fe | +0.6 | |
| Atletico Tucuman | +0.4 | |
| Chapecoense | +0.4 | |
| Libertad | +0.4 | |
| Penarol | +0.3 | |
|
| Gremio 4 Zamora 0 |
| 9:45 PM Thu | 100.0* | Lottery seed |
| Gremio | -4.9 | |
| Palmeiras | +0.4 | |
| Godoy Cruz | +0.4 | |
| Guarani | +1.3 | |
| Deportes Iquique | +1.2 | |
| Sport Boys | -0.4 | |
| Sporting Cristal | -0.4 | |
| Zamora | +1.0 | |
|
| Guarani 0 Deportes Iquique 0 |
| 9:45 PM Thu | 100.0* | Lottery seed |
| Gremio | +0.5 | |
| Guarani | -1.8 | |
| Deportes Iquique | +1.6 | |
| Flamengo | +0.4 | |