| Week of 4/5 |
| Deportivo Tachira 1 Emelec 0 |
| 7:30 PM Tue | 100.0* | Lottery seed |
| Deportivo Tachira | -5.0 | |
| Emelec | +4.6 | |
|
| Racing 4 Deportivo Cali 2 |
| 9:45 PM Thu | 100.0* | Lottery seed |
| Racing | -4.6 | |
| Deportivo Cali | +4.1 | |
|
| Melgar 1 Colo-Colo 2 |
| 9:45 PM Thu | 100.0* | Lottery seed |
| Independiente del Valle | +1.3 | |
| Colo-Colo | -4.9 | |
| Melgar | +2.0 | |
|
| Pumas 4 Olimpia 1 |
| 11:45 PM Thu | 100.0* | Lottery seed |
| Pumas | -3.3 | |
| Olimpia | +4.2 | |
|
| Boca Juniors 3 Bolivar 1 |
| 7:30 PM Thu | 100.0* | Lottery seed |
| Boca Juniors | -5.3 | |
| Bolivar | +4.8 | |
|
| Huracan 4 Sporting Cristal 2 |
| 7:30 PM Tue | 100.0* | Lottery seed |
| Huracan | -5.0 | |
| Sporting Cristal | +4.6 | |
|
| Toluca 2 LDU de Quito 1 |
| 9:45 PM Tue | 100.0* | Lottery seed |
| Toluca | -3.7 | |
| LDU de Quito | +4.2 | |
|
| Independiente del Valle 3 Atletico-MG 2 |
| 9:45 PM Wed | 100.0* | Lottery seed |
| Atletico-MG | +3.3 | |
| Independiente del Valle | -4.7 | |
| Colo-Colo | +0.6 | |
|
| River Plate 6 The Strongest 0 |
| 7:30 PM Wed | 100.0* | Lottery seed |
| River Plate | -4.8 | |
| The Strongest | +3.9 | |
|
| Sao Paulo 6 Trujillanos 0 |
| 9:45 PM Tue | 100.0* | Lottery seed |
| Sao Paulo | -4.8 | |
| Trujillanos | +3.7 | |
|
| River Plate-URU 2 Nacional 2 |
| 7:30 PM Thu | 100.0* | Lottery seed |
| Rosario Central | +0.2 | |
| Nacional | -0.2 | |
| River Plate-URU | +1.3 | |
|
| Rosario Central 3 Palmeiras 3 |
| 9:45 PM Wed | 100.0* | Lottery seed |
| Rosario Central | -0.1 | |
| Palmeiras | +1.2 | |
|
| Week of 4/12 |
| Palmeiras 4 River Plate-URU 0 |
| 9:45 PM Thu | 100.0* | Lottery seed |
| Rosario Central | +0.8 | |
| Palmeiras | -5.0 | |
| River Plate-URU | +3.2 | |
|
| LDU de Quito 2 Gremio 3 |
| 9:40 PM Wed | 100.0* | Lottery seed |
| Gremio | -4.5 | |
| LDU de Quito | +4.5 | |
|
| Racing 0 Boca Juniors 1 |
| 9:45 PM Wed | 100.0* | Lottery seed |
| Boca Juniors | -5.4 | |
| Racing | +4.0 | |
|
| Nacional 0 Rosario Central 2 |
| 9:45 PM Thu | 100.0* | Lottery seed |
| Rosario Central | -5.5 | |
| Nacional | +4.7 | |
| Palmeiras | +0.4 | |
|
| Olimpia 4 Deportivo Tachira 0 |
| 7:30 PM Wed | 100.0* | Lottery seed |
| Deportivo Tachira | +2.4 | |
| Olimpia | -3.9 | |
|
| Trujillanos 2 The Strongest 1 |
| 9:00 PM Tue | 100.0* | Lottery seed |
| River Plate | -0.7 | |
| Sao Paulo | -0.5 | |
| The Strongest | +3.5 | |
| Trujillanos | -2.9 | |
|
| Sao Paulo 2 River Plate 1 |
| 7:30 PM Wed | 100.0* | Lottery seed |
| River Plate | +3.6 | |
| Sao Paulo | -4.8 | |
|
| Emelec 2 Pumas 3 |
| 7:30 PM Wed | 100.0* | Lottery seed |
| Pumas | -2.0 | |
| Emelec | +3.5 | |
|
| Cobresal 2 Cerro Porteno 0 |
| 5:15 PM Wed | 100.0* | Lottery seed |
| Corinthians | -0.7 | |
| Cerro Porteno | +3.3 | |
| Santa Fe | -0.7 | |
| Cobresal | -2.5 | |
|
| Toluca 2 San Lorenzo 1 |
| 11:45 PM Tue | 100.0* | Lottery seed |
| Toluca | -2.3 | |
| San Lorenzo | +3.5 | |
|
| Atletico-MG 4 Melgar 0 |
| 7:30 PM Thu | 100.0* | Lottery seed |
| Atletico-MG | -3.6 | |
| Independiente del Valle | +1.4 | |
| Colo-Colo | +0.6 | |
| Melgar | +0.9 | |
|
| Sporting Cristal 0 Atletico Nacional 1 |
| 11:45 PM Tue | 100.0* | Lottery seed |
| Atletico Nacional | -1.2 | |
| Huracan | -0.5 | |
| Sporting Cristal | +3.6 | |
|
| Colo-Colo 0 Independiente del Valle 0 |
| 7:30 PM Thu | 100.0* | Lottery seed |
| Atletico-MG | -1.1 | |
| Independiente del Valle | -1.4 | |
| Colo-Colo | +2.7 | |
|
| Deportivo Cali 1 Bolivar 1 |
| 9:45 PM Thu | 100.0* | Lottery seed |
| Boca Juniors | -0.4 | |
| Bolivar | +0.5 | |
| Deportivo Cali | +1.6 | |
|
| Huracan 0 Penarol 0 |
| 7:30 PM Tue | 100.0* | Lottery seed |
| Huracan | +0.3 | |
| Penarol | +1.2 | |
| Sporting Cristal | -0.2 | |
|
| Santa Fe 1 Corinthians 1 |
| 9:45 PM Wed | 100.0* | Lottery seed |
| Corinthians | -0.2 | |
| Santa Fe | +0.8 | |
|
| Week of 4/19 |
| Corinthians 6 Cobresal 0 |
| 9:45 PM Wed | 100.0* | Lottery seed |
| Corinthians | -3.8 | |
| Cerro Porteno | +0.5 | |
| Santa Fe | +0.7 | |
| Cobresal | +3.7 | |
|
| River Plate 4 Trujillanos 3 |
| 9:45 PM Thu | 100.0* | Lottery seed |
| River Plate | -4.1 | |
| Sao Paulo | +0.9 | |
| The Strongest | +0.7 | |
| Trujillanos | +3.4 | |
|
| Cerro Porteno 1 Santa Fe 0 |
| 9:45 PM Wed | 100.0* | Lottery seed |
| Cerro Porteno | -6.6 | |
| Santa Fe | +6.5 | |
|
| Boca Juniors 6 Deportivo Cali 2 |
| 7:30 PM Wed | 100.0* | Lottery seed |
| Boca Juniors | -3.2 | |
| Racing | +1.1 | |
| Deportivo Cali | +3.2 | |
|
| Penarol 4 Sporting Cristal 3 |
| 7:30 PM Tue | 100.0* | Lottery seed |
| Huracan | -0.8 | |
| Penarol | -3.4 | |
| Sporting Cristal | +4.1 | |
| River Plate-URU | +0.4 | |
|
| Gremio 1 Toluca 0 |
| 9:45 PM Tue | 100.0* | Lottery seed |
| Toluca | +1.4 | |
| Gremio | -3.1 | |
|
| The Strongest 1 Sao Paulo 1 |
| 9:45 PM Thu | 100.0* | Lottery seed |
| River Plate | -1.0 | |
| Sao Paulo | -2.1 | |
| The Strongest | +3.6 | |
|
| Bolivar 1 Racing 1 |
| 7:30 PM Wed | 100.0* | Lottery seed |
| Boca Juniors | +0.4 | |
| Racing | -1.8 | |
| Bolivar | +2.5 | |
|
| Atletico Nacional 0 Huracan 0 |
| 7:30 PM Tue | 100.0* | Lottery seed |
| Atletico Nacional | -0.3 | |
| Huracan | +0.9 | |
| Sporting Cristal | +0.7 | |
|
| San Lorenzo 1 LDU de Quito 1 |
| 9:45 PM Tue | 100.0* | Lottery seed |
| San Lorenzo | -0.8 | |
| LDU de Quito | +0.7 | |