| Week of 4/7 |
| Atletico-MG 2 Santa Fe 0 |
| 9:45 PM Thu | 100.0* | Lottery seed |
| Santa Fe | +4.7 | |
| Atletico-MG | -5.5 | |
|
| Estudiantes 0 Atletico Nacional 1 |
| 7:30 PM Thu | 100.0* | Lottery seed |
| Atletico Nacional | -6.5 | |
| Estudiantes | +5.4 | |
|
| Guarani 2 Racing 0 |
| 8:00 PM Tue | 100.0* | Lottery seed |
| Racing | +2.6 | |
| Guarani | -4.8 | |
|
| Libertad 1 Barcelona 1 |
| 7:30 PM Thu | 100.0* | Lottery seed |
| Estudiantes | -0.6 | |
| Libertad | +2.3 | |
| Barcelona | -0.4 | |
|
| Palestino 4 Zamora 0 |
| 8:00 PM Tue | 100.0* | Lottery seed |
| Palestino | -2.5 | |
| Zamora | +0.9 | |
|
| Tigres 2 River Plate 2 |
| 10:00 PM Wed | 100.0* | Lottery seed |
| Tigres | +1.2 | |
| River Plate | -1.6 | |
| Juan Aurich | +0.7 | |
|
| Atlas 1 Colo-Colo 3 |
| 10:15 PM Tue | 100.0* | Lottery seed |
| Colo-Colo | -1.7 | |
| Atlas | +1.7 | |
|
| Huracan 1 Universitario de Sucre 1 |
| 7:45 PM Wed | 100.0* | Lottery seed |
| Universitario de Sucre | +1.8 | |
| Huracan | -0.9 | |
|
| Deportivo Tachira 0 Sporting Cristal 0 |
| 7:45 PM Wed | 100.0* | Lottery seed |
| Sporting Cristal | +1.3 | |
| Deportivo Tachira | +0.3 | |
|
| Wanderers 0 Boca Juniors 3 |
| 9:45 PM Thu | 100.0* | Lottery seed |
| Boca Juniors | -0.6 | |
| Wanderers | +1.4 | |
| Palestino | -0.4 | |
|
| Cruzeiro 3 Mineros de Guayana 0 |
| 10:00 PM Wed | 100.0* | Lottery seed |
| Cruzeiro | -1.1 | |
| Universitario de Sucre | +0.2 | |
| Mineros de Guayana | +0.6 | |
|
| San Jose 1 Juan Aurich 1 |
| 10:15 PM Tue | 100.0* | Lottery seed |
| River Plate | -0.6 | |
| Juan Aurich | +1.1 | |
|
| Week of 4/14 |
| Huracan 3 Cruzeiro 1 |
| 7:00 PM Tue | 100.0* | Lottery seed |
| Cruzeiro | +4.2 | |
| Universitario de Sucre | +1.3 | |
| Huracan | -7.4 | |
|
| Atlas 1 Atletico-MG 0 |
| 10:00 PM Wed | 100.0* | Lottery seed |
| Santa Fe | -0.9 | |
| Atletico-MG | +6.0 | |
| Atlas | -4.0 | |
|
| Colo-Colo 0 Santa Fe 3 |
| 10:00 PM Wed | 100.0* | Lottery seed |
| Santa Fe | -6.9 | |
| Atletico-MG | +0.6 | |
| Colo-Colo | +4.8 | |
|
| The Strongest 1 Emelec 0 |
| 5:30 PM Wed | 100.0* | Lottery seed |
| Emelec | +5.1 | |
| The Strongest | -6.1 | |
|
| River Plate 3 San Jose 0 |
| 7:45 PM Wed | 100.0* | Lottery seed |
| River Plate | -3.9 | |
| Juan Aurich | +1.6 | |
| San Jose | +2.1 | |
|
| Juan Aurich 4 Tigres 5 |
| 7:45 PM Wed | 100.0* | Lottery seed |
| Tigres | -0.9 | |
| Racing | +0.2 | |
| River Plate | -0.7 | |
| Juan Aurich | +2.2 | |
| San Jose | -0.4 | |
|
| Danubio 1 Sao Paulo 2 |
| 10:00 PM Wed | 100.0* | Lottery seed |
| Sao Paulo | -2.0 | |
| San Lorenzo | +0.7 | |
| Danubio | +0.5 | |
|
| Sporting Cristal 1 Guarani 1 |
| 9:15 PM Tue | 100.0* | Lottery seed |
| Guarani | -0.6 | |
| Sporting Cristal | +1.8 | |
|
| Universitario de Sucre 2 Mineros de Guayana 0 |
| 7:00 PM Tue | 100.0* | Lottery seed |
| Universitario de Sucre | -1.7 | |
| Huracan | +0.5 | |
| Mineros de Guayana | +0.5 | |
|
| Racing 3 Deportivo Tachira 2 |
| 9:15 PM Tue | 100.0* | Lottery seed |
| Racing | -1.1 | |
| Guarani | +0.4 | |
| Deportivo Tachira | +0.6 | |
|
| Week of 4/21 |
| Mineros de Guayana 3 Huracan 0 |
| 8:30 PM Tue | 100.0* | Lottery seed |
| Cruzeiro | -2.5 | |
| Universitario de Sucre | -1.2 | |
| Huracan | +8.4 | |
| Mineros de Guayana | -2.9 | |
| Deportivo Tachira | +0.9 | |
|
| Atletico-MG 2 Colo-Colo 0 |
| 7:45 PM Wed | 100.0* | Lottery seed |
| Santa Fe | -0.7 | |
| Atletico-MG | -5.4 | |
| Colo-Colo | +5.3 | |
| Libertad | +0.7 | |
| Palestino | +0.7 | |
| Sporting Cristal | +0.5 | |
| Huracan | +0.5 | |
|
| Cruzeiro 2 Universitario de Sucre 0 |
| 8:30 PM Tue | 100.0* | Lottery seed |
| Cruzeiro | -7.6 | |
| Universitario de Sucre | +6.8 | |
| Huracan | +0.7 | |
|
| San Lorenzo 0 Danubio 1 |
| 10:00 PM Wed | 100.0* | Lottery seed |
| Sao Paulo | -1.7 | |
| Libertad | -0.9 | |
| Palestino | -0.9 | |
| San Lorenzo | +6.9 | |
| Danubio | -0.9 | |
|
| Sao Paulo 2 Corinthians 0 |
| 10:00 PM Wed | 100.0* | Lottery seed |
| Tigres | -0.6 | |
| Corinthians | +0.9 | |
| Sao Paulo | -4.9 | |
| San Lorenzo | +2.7 | |
|
| Atletico Nacional 4 Libertad 0 |
| 10:45 PM Tue | 100.0* | Lottery seed |
| Atletico Nacional | -4.9 | |
| Libertad | +4.6 | |
|
| Barcelona 0 Estudiantes 2 |
| 10:45 PM Tue | 100.0* | Lottery seed |
| Atletico Nacional | +1.0 | |
| Estudiantes | -3.9 | |
| Libertad | +0.8 | |
| Juan Aurich | -0.2 | |
| Barcelona | +1.0 | |
|
| Emelec 2 Universidad de Chile 0 |
| 5:30 PM Wed | 100.0* | Lottery seed |
| Emelec | -3.2 | |
| The Strongest | +1.0 | |
| San Jose | -0.4 | |
| Universidad de Chile | +1.0 | |
|
| Internacional 1 The Strongest 0 |
| 5:30 PM Wed | 100.0* | Lottery seed |
| Internacional | -2.5 | |
| Racing | +0.4 | |
| Emelec | -0.3 | |
| The Strongest | +2.9 | |
|
| Santa Fe 3 Atlas 1 |
| 7:45 PM Wed | 100.0* | Lottery seed |
| Santa Fe | -2.0 | |
| Colo-Colo | +0.5 | |
| Juan Aurich | -0.4 | |
| Atlas | +1.5 | |