| Week of 3/25 |
| Leon 0 Bolivar 1 |
| 12:15 AM Thu | 100.0* | Lottery seed |
| Bolivar | -5.9 | |
| Leon | +5.3 | |
|
| Lanus 2 Cerro Porteno 0 |
| 6:30 PM Thu | 100.0* | Lottery seed |
| Cerro Porteno | +5.0 | |
| Lanus | -5.7 | |
|
| Zamora 2 Nacional-PAR 0 |
| 8:45 PM Tue | 100.0* | Lottery seed |
| Nacional-PAR | +5.5 | |
| Zamora | -6.0 | |
|
| Nacional 2 Newell's Old Boys 4 |
| 7:45 PM Wed | 100.0* | Lottery seed |
| Gremio | +0.8 | |
| Atletico Nacional | +0.7 | |
| Newell's Old Boys | -5.3 | |
| Nacional | +2.4 | |
|
| Santos Laguna 4 Penarol 1 |
| 11:00 PM Tue | 100.0* | Lottery seed |
| Santos Laguna | -2.6 | |
| Penarol | +4.4 | |
|
| Deportivo Anzoategui 1 Arsenal 3 |
| 7:45 PM Wed | 100.0* | Lottery seed |
| Arsenal | -4.1 | |
| Penarol | +0.5 | |
| Deportivo Anzoategui | +3.3 | |
|
| Atletico-PR 1 Velez Sarsfield 3 |
| 10:00 PM Wed | 100.0* | Lottery seed |
| Velez Sarsfield | -4.5 | |
| Atletico-PR | +4.4 | |
|
| Independiente del Valle 1 San Lorenzo 1 |
| 8:45 PM Thu | 100.0* | Lottery seed |
| Union Espanola | -0.9 | |
| San Lorenzo | +1.5 | |
| Independiente del Valle | +1.4 | |
|
| Deportivo Cali 1 O'Higgins 1 |
| 10:00 PM Wed | 100.0* | Lottery seed |
| O'Higgins | +1.4 | |
| Deportivo Cali | +0.8 | |
|
| Universitario 3 The Strongest 3 |
| 11:00 PM Thu | 100.0* | Lottery seed |
| The Strongest | +0.6 | |
| Atletico-PR | -0.2 | |
| Universitario | +0.6 | |
|
| Week of 4/1 |
| Botafogo 0 Union Espanola 1 |
| 7:45 PM Wed | 100.0* | Lottery seed |
| Union Espanola | -6.6 | |
| Independiente del Valle | +0.5 | |
| Botafogo | +5.8 | |
|
| Emelec 1 Flamengo 2 |
| 10:00 PM Wed | 100.0* | Lottery seed |
| Leon | -0.2 | |
| Flamengo | -5.7 | |
| Emelec | +4.9 | |
|
| Real Garcilaso 0 Defensor Sporting 2 |
| 9:00 PM Tue | 100.0* | Lottery seed |
| Defensor Sporting | -4.7 | |
| Universidad de Chile | +0.8 | |
| Real Garcilaso | +3.9 | |
|
| Atletico Nacional 0 Gremio 2 |
| 10:00 PM Wed | 100.0* | Lottery seed |
| Gremio | -5.0 | |
| Atletico Nacional | +4.8 | |
| Newell's Old Boys | +0.7 | |
|
| Universidad de Chile 0 Cruzeiro 2 |
| 8:45 PM Thu | 100.0* | Lottery seed |
| Cruzeiro | -5.2 | |
| Universidad de Chile | +2.7 | |
|
| Santa Fe 1 Atletico-MG 1 |
| 11:00 PM Thu | 100.0* | Lottery seed |
| Atletico-MG | +0.7 | |
| Zamora | -1.1 | |
| Santa Fe | +1.8 | |
|
| Week of 4/8 |
| San Lorenzo 3 Botafogo 0 |
| 10:00 PM Wed | 100.0* | Lottery seed |
| Union Espanola | -1.2 | |
| San Lorenzo | -6.8 | |
| Botafogo | +7.7 | |
|
| Bolivar 2 Emelec 1 |
| 7:45 PM Wed | 100.0* | Lottery seed |
| Bolivar | -7.1 | |
| Leon | +0.8 | |
| Flamengo | +0.8 | |
| O'Higgins | -0.4 | |
| Deportivo Cali | -0.4 | |
| Emelec | +6.3 | |
|
| Atletico-MG 1 Zamora 0 |
| 5:30 PM Thu | 100.0* | Lottery seed |
| Atletico-MG | -4.7 | |
| Defensor Sporting | +0.6 | |
| Bolivar | +0.6 | |
| Nacional-PAR | -0.9 | |
| Zamora | +7.7 | |
| Santa Fe | -0.8 | |
|
| Newell's Old Boys 1 Atletico Nacional 3 |
| 10:00 PM Thu | 100.0* | Lottery seed |
| Gremio | -0.7 | |
| Atletico Nacional | -7.4 | |
| Newell's Old Boys | +6.6 | |
|
| Flamengo 2 Leon 3 |
| 7:45 PM Wed | 100.0* | Lottery seed |
| Leon | -7.4 | |
| Flamengo | +6.9 | |
| Emelec | +0.4 | |
|
| Cerro Porteno 3 Deportivo Cali 2 |
| 10:00 PM Tue | 100.0* | Lottery seed |
| Cerro Porteno | -7.5 | |
| Lanus | +0.4 | |
| O'Higgins | +0.4 | |
| Deportivo Cali | +6.6 | |
|
| Cruzeiro 3 Real Garcilaso 0 |
| 10:00 PM Wed | 100.0* | Lottery seed |
| Defensor Sporting | +1.4 | |
| Cruzeiro | -6.5 | |
| Universidad de Chile | +1.7 | |
| Real Garcilaso | +1.7 | |
|
| The Strongest 2 Atletico-PR 1 |
| 7:45 PM Tue | 100.0* | Lottery seed |
| Velez Sarsfield | -0.8 | |
| The Strongest | -6.3 | |
| Atletico-PR | +5.2 | |
|
| Union Espanola 4 Independiente del Valle 5 |
| 10:00 PM Wed | 100.0* | Lottery seed |
| Union Espanola | +2.8 | |
| San Lorenzo | +0.7 | |
| Independiente del Valle | -5.9 | |
| O'Higgins | +0.6 | |
| Deportivo Cali | +0.6 | |
|
| Nacional-PAR 3 Santa Fe 2 |
| 5:30 PM Thu | 100.0* | Lottery seed |
| Nacional-PAR | -6.3 | |
| Zamora | +0.6 | |
| Emelec | -0.2 | |
| Santa Fe | +5.2 | |
|
| Defensor Sporting 1 Universidad de Chile 1 |
| 10:00 PM Wed | 100.0* | Lottery seed |
| Defensor Sporting | -2.8 | |
| Universidad de Chile | +3.4 | |
|
| Gremio 1 Nacional 0 |
| 10:00 PM Thu | 100.0* | Lottery seed |
| Gremio | -1.9 | |
| Newell's Old Boys | +1.0 | |
| Real Garcilaso | -0.4 | |
| Nacional | +1.5 | |
|
| Velez Sarsfield 1 Universitario 0 |
| 7:45 PM Tue | 100.0* | Lottery seed |
| Velez Sarsfield | -2.1 | |
| Atletico-PR | +0.9 | |
| Universitario | +1.0 | |
|
| O'Higgins 0 Lanus 0 |
| 10:00 PM Tue | 100.0* | Lottery seed |
| Lanus | -1.0 | |
| O'Higgins | +1.7 | |
|
| Arsenal 3 Santos Laguna 0 |
| 7:45 PM Thu | 100.0* | Lottery seed |
| Santos Laguna | +0.6 | |
| Arsenal | -2.0 | |
| Cruzeiro | +0.6 | |
|
| Penarol 1 Deportivo Anzoategui 1 |
| 7:45 PM Thu | 100.0* | Lottery seed |
| Emelec | -0.4 | |
| Penarol | +1.2 | |
| Deportivo Anzoategui | +0.3 | |
| Real Garcilaso | +0.4 | |