| Week of 4/2 |
| Real Garcilaso 0 Tolima 3 |
| 7:15 PM Tue | 100.0* | Lottery seed |
| Real Garcilaso | +4.0 | |
| Tolima | -5.7 | |
|
| Caracas 0 Huachipato 4 |
| 7:45 PM Wed | 100.0* | Lottery seed |
| Huachipato | -5.0 | |
| Caracas | +4.6 | |
|
| The Strongest 2 Sao Paulo 1 |
| 9:30 PM Thu | 100.0* | Lottery seed |
| Sao Paulo | +5.2 | |
| Arsenal | -0.6 | |
| The Strongest | -4.7 | |
|
| Boca Juniors 1 Barcelona 0 |
| 7:45 PM Wed | 100.0* | Lottery seed |
| Nacional | +0.5 | |
| Boca Juniors | -4.1 | |
| Toluca | +0.4 | |
| Barcelona | +3.6 | |
|
| Nacional 4 Toluca 0 |
| 7:15 PM Thu | 100.0* | Lottery seed |
| Nacional | -4.2 | |
| Toluca | +4.4 | |
|
| Emelec 2 Penarol 0 |
| 11:45 PM Tue | 100.0* | Lottery seed |
| Emelec | -5.1 | |
| Penarol | +4.6 | |
|
| Palmeiras 2 Tigre 0 |
| 9:30 PM Tue | 100.0* | Lottery seed |
| Palmeiras | -3.6 | |
| Tigre | +3.0 | |
|
| Newell's Old Boys 3 Deportivo Lara 1 |
| 7:15 PM Thu | 100.0* | Lottery seed |
| Newell's Old Boys | -2.9 | |
| Universidad de Chile | +0.4 | |
| Deportivo Lara | +2.3 | |
|
| Universidad de Chile 0 Olimpia 1 |
| 10:45 PM Thu | 100.0* | Lottery seed |
| Olimpia | -2.8 | |
| Universidad de Chile | +2.9 | |
|
| Santa Fe 1 Cerro Porteno 0 |
| 9:30 PM Tue | 100.0* | Lottery seed |
| Santa Fe | -2.4 | |
| Tolima | +0.4 | |
| Cerro Porteno | +1.0 | |
|
| San Jose 1 Tijuana 1 |
| 7:45 PM Wed | 100.0* | Lottery seed |
| Corinthians | -1.1 | |
| Tijuana | +2.0 | |
| San Jose | -0.4 | |
|
| Atletico-MG 5 Arsenal 2 |
| 10:00 PM Wed | 100.0* | Lottery seed |
| Atletico-MG | -0.5 | |
| Sao Paulo | -0.4 | |
| Arsenal | +1.8 | |
|
| Deportes Iquique 1 Velez Sarsfield 3 |
| 7:15 PM Tue | 100.0* | Lottery seed |
| Velez Sarsfield | -1.1 | |
| Deportes Iquique | +1.5 | |
|
| Millonarios 0 Corinthians 1 |
| 10:00 PM Wed | 100.0* | Lottery seed |
| Corinthians | -1.1 | |
| Tijuana | +0.4 | |
| Millonarios | +1.0 | |
|
| Week of 4/9 |
| Tigre 3 Sporting Cristal 1 |
| 7:15 PM Tue | 100.0* | Lottery seed |
| Tigre | -6.4 | |
| Sporting Cristal | +5.8 | |
|
| Palmeiras 1 Libertad 0 |
| 7:15 PM Thu | 100.0* | Lottery seed |
| Palmeiras | -6.1 | |
| Libertad | +4.9 | |
| Sporting Cristal | +1.0 | |
|
| Penarol 3 Deportes Iquique 0 |
| 9:30 PM Tue | 100.0* | Lottery seed |
| Emelec | +0.7 | |
| Penarol | -3.6 | |
| Deportes Iquique | +3.5 | |
|
| Tolima 1 Santa Fe 2 |
| 10:00 PM Tue | 100.0* | Lottery seed |
| Santa Fe | -4.7 | |
| Tolima | +4.8 | |
|
| Olimpia 4 Newell's Old Boys 1 |
| 9:30 PM Thu | 100.0* | Lottery seed |
| Olimpia | -3.6 | |
| Velez Sarsfield | +0.6 | |
| Newell's Old Boys | +3.8 | |
|
| Deportivo Lara 2 Universidad de Chile 3 |
| 9:30 PM Thu | 100.0* | Lottery seed |
| Universidad de Chile | -2.9 | |
| Deportivo Lara | +2.8 | |
|
| Real Garcilaso 5 Cerro Porteno 1 |
| 7:45 PM Wed | 100.0* | Lottery seed |
| Real Garcilaso | -2.8 | |
| Tolima | +1.0 | |
| Cerro Porteno | +0.8 | |
|
| Corinthians 3 San Jose 0 |
| 10:00 PM Wed | 100.0* | Lottery seed |
| Corinthians | -1.4 | |
| Tijuana | +0.7 | |
| San Jose | +1.2 | |
|
| Gremio 0 Fluminense 0 |
| 10:30 PM Wed | 100.0* | Lottery seed |
| Fluminense | -0.8 | |
| Gremio | +1.5 | |
| Caracas | -0.7 | |
|
| Tijuana 1 Millonarios 0 |
| 10:00 PM Wed | 100.0* | Lottery seed |
| Corinthians | +0.4 | |
| Tijuana | -1.0 | |
| Millonarios | +1.1 | |
|
| Velez Sarsfield 0 Emelec 0 |
| 9:30 PM Tue | 100.0* | Lottery seed |
| Velez Sarsfield | +0.6 | |
| Emelec | -1.0 | |
|
| Week of 4/16 |
| Libertad 3 Tigre 5 |
| 10:15 PM Thu | 100.0* | Lottery seed |
| Palmeiras | -0.9 | |
| Tigre | -10.4 | |
| Libertad | +9.5 | |
|
| Barcelona 1 Nacional 0 |
| 7:45 PM Wed | 100.0* | Lottery seed |
| Nacional | +3.6 | |
| Boca Juniors | -1.5 | |
| Barcelona | -5.1 | |
| San Jose | +0.8 | |
|
| Sporting Cristal 1 Palmeiras 0 |
| 10:15 PM Thu | 100.0* | Lottery seed |
| Palmeiras | +4.6 | |
| Libertad | -1.7 | |
| Sporting Cristal | -4.4 | |
| Toluca | +0.7 | |
|
| Fluminense 1 Caracas 0 |
| 8:00 PM Thu | 100.0* | Lottery seed |
| Fluminense | -5.8 | |
| Gremio | +0.7 | |
| Caracas | +4.9 | |
|
| Arsenal 2 The Strongest 1 |
| 10:00 PM Wed | 100.0* | Lottery seed |
| Arsenal | -7.0 | |
| The Strongest | +5.8 | |
| San Jose | +0.5 | |
|
| Toluca 3 Boca Juniors 2 |
| 7:45 PM Wed | 100.0* | Lottery seed |
| Nacional | -0.8 | |
| Boca Juniors | +4.4 | |
| Toluca | -3.4 | |
|
| Santa Fe 2 Real Garcilaso 0 |
| 10:15 PM Tue | 100.0* | Lottery seed |
| Santa Fe | -4.1 | |
| Real Garcilaso | +5.0 | |
| Tolima | -2.4 | |
|
| Sao Paulo 2 Atletico-MG 0 |
| 10:00 PM Wed | 100.0* | Lottery seed |
| Sao Paulo | -5.8 | |
| Arsenal | +1.4 | |
| The Strongest | +0.8 | |
| San Jose | +0.6 | |
|
| Huachipato 1 Gremio 1 |
| 8:00 PM Thu | 100.0* | Lottery seed |
| Fluminense | -0.8 | |
| Gremio | +0.8 | |
| Huachipato | +2.0 | |
| Tolima | +0.8 | |
| Toluca | +0.8 | |
| Caracas | -1.6 | |
|
| Cerro Porteno 0 Tolima 0 |
| 10:15 PM Tue | 100.0* | Lottery seed |
| Real Garcilaso | -1.5 | |
| Tolima | +3.1 | |
| Cerro Porteno | +0.2 | |