| Week of 4/3 |
| Libertad 2 Nacional 1 |
| Thu | 100.0* | Lottery seed |
| Libertad | -5.5 | |
| Nacional | +5.6 | |
|
| Alianza Lima 1 Vasco da Gama 2 |
| Tue | 100.0* | Lottery seed |
| Libertad | +0.7 | |
| Vasco da Gama | -4.6 | |
| Nacional | +0.4 | |
| Alianza Lima | +3.7 | |
|
| Emelec 3 Flamengo 2 |
| Wed | 100.0* | Lottery seed |
| Lanus | -0.7 | |
| Emelec | -4.3 | |
| Flamengo | +5.0 | |
| Olimpia | -0.4 | |
|
| Junior 3 Universidad Catolica 0 |
| Wed | 100.0* | Lottery seed |
| Union Espanola | -0.6 | |
| Bolivar | -0.6 | |
| Junior | -3.3 | |
| Universidad Catolica | +4.6 | |
|
| Godoy Cruz 0 Universidad de Chile 1 |
| Wed | 100.0* | Lottery seed |
| Universidad de Chile | -4.8 | |
| Godoy Cruz | +4.9 | |
|
| Lanus 6 Olimpia 0 |
| Tue | 100.0* | Lottery seed |
| Lanus | -5.4 | |
| Olimpia | +5.3 | |
|
| Juan Aurich 1 The Strongest 0 |
| Thu | 100.0* | Lottery seed |
| Santos | -0.8 | |
| Internacional | -0.9 | |
| The Strongest | +4.1 | |
| Juan Aurich | -2.1 | |
|
| Deportivo Tachira 1 Cruz Azul 1 |
| Tue | 100.0* | Lottery seed |
| Corinthians | -0.3 | |
| Cruz Azul | +0.0 | |
| Deportivo Tachira | +1.6 | |
|
| Internacional 1 Santos 1 |
| Wed | 100.0* | Lottery seed |
| Santos | -0.1 | |
| Internacional | +1.1 | |
|
| Week of 4/10 |
| Nacional 0 Vasco da Gama 1 |
| Thu | 100.0* | Lottery seed |
| Libertad | +1.3 | |
| Vasco da Gama | -3.5 | |
| Nacional | +3.7 | |
|
| Alianza Lima 1 Libertad 2 |
| Thu | 100.0* | Lottery seed |
| Libertad | -3.5 | |
| Vasco da Gama | +1.3 | |
| Alianza Lima | +3.1 | |
|
| Flamengo 3 Lanus 0 |
| Thu | 100.0* | Lottery seed |
| Lanus | +2.5 | |
| Flamengo | -4.7 | |
|
| Nacional-PAR 1 Corinthians 3 |
| Wed | 100.0* | Lottery seed |
| Corinthians | -4.0 | |
| Nacional-PAR | +4.9 | |
|
| Deportivo Quito 2 Defensor Sporting 0 |
| Tue | 100.0* | Lottery seed |
| Deportivo Quito | -5.5 | |
| Defensor Sporting | +5.3 | |
|
| Olimpia 2 Emelec 3 |
| Thu | 100.0* | Lottery seed |
| Emelec | -5.5 | |
| Flamengo | +0.4 | |
| Olimpia | +5.2 | |
|
| Guadalajara 0 Velez Sarsfield 2 |
| Wed | 100.0* | Lottery seed |
| Velez Sarsfield | -3.7 | |
| Guadalajara | +4.5 | |
|
| Union Espanola 2 Bolivar 1 |
| Tue | 100.0* | Lottery seed |
| Union Espanola | -5.5 | |
| Bolivar | +5.0 | |
| Junior | +0.4 | |
|
| Atletico Nacional 3 Penarol 0 |
| Tue | 100.0* | Lottery seed |
| Atletico Nacional | -3.2 | |
| Penarol | +2.6 | |
|
| Zamora 0 Arsenal 1 |
| Tue | 100.0* | Lottery seed |
| Arsenal | -4.3 | |
| Zamora | +2.9 | |
|
| Fluminense 0 Boca Juniors 2 |
| Wed | 100.0* | Lottery seed |
| Fluminense | +1.7 | |
| Boca Juniors | -3.9 | |
| Arsenal | +0.7 | |
|
| Week of 4/17 |
| Junior 2 Union Espanola 1 |
| Tue | 100.0* | Lottery seed |
| Union Espanola | +3.3 | |
| Bolivar | -0.8 | |
| Junior | -4.6 | |
|
| Bolivar 3 Universidad Catolica 0 |
| Tue | 100.0* | Lottery seed |
| Union Espanola | +1.1 | |
| Bolivar | -5.5 | |
| Emelec | +0.2 | |
| Nacional | -0.6 | |
| Universidad Catolica | +5.4 | |
|
| Cruz Azul 4 Nacional-PAR 1 |
| Wed | 100.0* | Lottery seed |
| Corinthians | +1.3 | |
| Cruz Azul | -4.2 | |
| Emelec | +0.4 | |
| Nacional-PAR | +3.4 | |
|
| Arsenal 1 Fluminense 2 |
| Wed | 100.0* | Lottery seed |
| Fluminense | -3.4 | |
| Boca Juniors | +1.6 | |
| Defensor Sporting | -0.4 | |
| Arsenal | +3.9 | |
|
| Juan Aurich 1 Internacional 0 |
| Thu | 100.0* | Lottery seed |
| Santos | -1.1 | |
| Internacional | +4.0 | |
| The Strongest | -0.8 | |
| Juan Aurich | -3.2 | |
| Guadalajara | +0.4 | |
| Alianza Lima | +0.4 | |
|
| Velez Sarsfield 1 Defensor Sporting 3 |
| Tue | 100.0* | Lottery seed |
| Velez Sarsfield | +2.0 | |
| Deportivo Quito | +0.8 | |
| Defensor Sporting | -5.0 | |
| Olimpia | +0.4 | |
| Guadalajara | +0.7 | |
|
| Deportivo Quito 5 Guadalajara 0 |
| Tue | 100.0* | Lottery seed |
| Deportivo Quito | -4.3 | |
| Defensor Sporting | +0.6 | |
| Nacional | -0.4 | |
| Guadalajara | +4.4 | |
|
| Santos 2 The Strongest 0 |
| Thu | 100.0* | Lottery seed |
| Santos | -4.8 | |
| Internacional | +0.6 | |
| The Strongest | +4.0 | |
|
| Universidad de Chile 2 Atletico Nacional 1 |
| Thu | 100.0* | Lottery seed |
| Universidad de Chile | -6.2 | |
| Atletico Nacional | +5.4 | |
|
| Boca Juniors 2 Zamora 0 |
| Wed | 100.0* | Lottery seed |
| Fluminense | +2.0 | |
| Boca Juniors | -4.6 | |
| Guadalajara | -0.4 | |
| Alianza Lima | -0.4 | |
| Zamora | +1.7 | |
|
| Corinthians 6 Deportivo Tachira 0 |
| Wed | 100.0* | Lottery seed |
| Corinthians | -3.0 | |
| Cruz Azul | +0.8 | |
| Guadalajara | -0.6 | |
| Deportivo Tachira | +3.2 | |
|
| Penarol 4 Godoy Cruz 2 |
| Thu | 100.0* | Lottery seed |
| Godoy Cruz | +2.8 | |
| Penarol | -3.0 | |