| Week of 10/19 |
| Santos Laguna vs MunicipalIf winner is:HomeDrawAway | |
| Tue | 100.0* | Lottery seed |
| Monterrey | 1.21.11.1 | |
| Cruz Azul | 3.53.33.4 | |
| Santos Laguna | 2.34.48.1 | |
| Olimpia | 5.45.05.2 | |
| Columbus Crew | 5.74.55.2 | |
| Real Salt Lake | 5.65.35.2 | |
| Toluca | 7.07.17.2 | |
| Saprissa | 7.47.47.5 | |
| Puerto Rico Isl | 7.47.77.7 | |
| Municipal | 10.09.34.7 | |
| Toronto FC | 11.511.711.7 | |
|
| Olimpia vs Puerto Rico IslHomeDrawAway | |
| Wed | 100.0* | Lottery seed |
| Cruz Azul | 3.63.33.3 | |
| Santos Laguna | 4.34.24.2 | |
| Olimpia | 3.24.08.7 | |
| Columbus Crew | 5.55.25.2 | |
| Toluca | 6.87.37.3 | |
| Puerto Rico Isl | 9.98.84.0 | |
| Municipal | 8.38.68.7 | |
| Toronto FC | 11.511.711.7 | |
|
| Toluca vs FASHomeDrawAway | |
| Wed | 100.0* | Lottery seed |
| Cruz Azul | 3.53.33.3 | |
| Olimpia | 5.54.94.9 | |
| Columbus Crew | 5.45.15.1 | |
| Real Salt Lake | 5.65.15.1 | |
| Toluca | 6.18.810.6 | |
| Saprissa | 7.67.17.0 | |
| Puerto Rico Isl | 7.87.36.4 | |
| Municipal | 8.68.58.1 | |
| Toronto FC | 11.611.611.3 | |
| Sounders | 13.213.214.0 | |
| Árabe Unido | 13.413.914.1 | |
| FAS | 15.214.613.4 | |
| Joe Public | 15.715.815.9 | |
|
| Joe Public vs Columbus CrewHomeDrawAway | |
| Thu | 100.0* | Lottery seed |
| Cruz Azul | 3.23.23.6 | |
| Santos Laguna | 3.53.64.6 | |
| Olimpia | 5.15.35.3 | |
| Columbus Crew | 7.97.54.1 | |
| Real Salt Lake | 5.05.25.6 | |
| Toluca | 6.76.77.3 | |
| Saprissa | 7.17.17.6 | |
| Puerto Rico Isl | 7.57.57.6 | |
| Municipal | 8.38.38.7 | |
| Sounders | 13.813.213.2 | |
| Árabe Unido | 14.113.513.5 | |
| FAS | 15.715.014.8 | |
| Joe Public | 13.915.816.0 | |
|
| Real Salt Lake vs Cruz AzulHomeDrawAway | |
| Tue | 100.0* | Lottery seed |
| Monterrey | 1.21.11.2 | |
| Cruz Azul | 6.23.22.0 | |
| Santos Laguna | 4.14.14.4 | |
| Olimpia | 5.45.05.4 | |
| Columbus Crew | 5.45.15.3 | |
| Real Salt Lake | 2.45.57.1 | |
| Toluca | 7.17.56.8 | |
| Saprissa | 7.67.77.2 | |
| Municipal | 8.58.68.5 | |
|
| Marathón vs MonterreyHomeDrawAway | |
| Wed | 100.0* | Lottery seed |
| Monterrey | 2.41.01.0 | |
| Cruz Azul | 3.03.53.5 | |
| Santos Laguna | 3.84.34.3 | |
| Olimpia | 5.15.35.3 | |
| Real Salt Lake | 5.25.45.4 | |
| Toluca | 7.27.17.1 | |
| Saprissa | 8.57.37.3 | |
| Puerto Rico Isl | 7.87.57.5 | |
| Municipal | 8.98.58.5 | |
| Marathón | 9.011.512.0 | |
| Toronto FC | 12.111.711.5 | |
| Sounders | 13.413.413.2 | |
| Árabe Unido | 13.613.613.5 | |
|
| Toronto FC vs Árabe UnidoHomeDrawAway | |
| Tue | 100.0* | Lottery seed |
| Puerto Rico Isl | 7.67.57.5 | |
| Municipal | 8.68.48.4 | |
| Marathón | 11.811.411.2 | |
| Toronto FC | 10.711.613.2 | |
| Sounders | 13.013.413.6 | |
| Árabe Unido | 14.413.511.9 | |
| FAS | 14.815.015.1 | |
| Joe Public | 15.715.815.8 | |
|
| Sounders vs SaprissaHomeDrawAway | |
| Tue | 100.0* | Lottery seed |
| Olimpia | 5.25.25.3 | |
| Columbus Crew | 5.15.15.4 | |
| Real Salt Lake | 5.15.15.6 | |
| Toluca | 7.07.07.2 | |
| Saprissa | 8.48.26.8 | |
| Puerto Rico Isl | 7.57.57.6 | |
| Marathón | 11.711.411.6 | |
| Toronto FC | 12.111.511.5 | |
| Sounders | 11.913.313.7 | |
| Árabe Unido | 14.013.613.4 | |
| FAS | 15.014.914.9 | |
| Joe Public | 15.815.815.7 | |