| Week of 4/14 |
| Caracas 1 Everton 0 |
| Tue | 100.0* | Lottery seed |
| Caracas | -5.5 | |
| Everton | +4.7 | |
|
| Deportivo Quito 3 Universitario de Sucre 1 |
| Tue | 100.0* | Lottery seed |
| Cruzeiro | +1.1 | |
| Estudiantes | +0.6 | |
| Deportivo Quito | -4.9 | |
| Universitario de Sucre | +2.5 | |
|
| Deportivo Tachira 2 Guarani 1 |
| Thu | 100.0* | Lottery seed |
| Deportivo Cuenca | +0.9 | |
| Deportivo Tachira | -4.3 | |
| Guarani | +1.9 | |
|
| Independiente Medellin 2 Sao Paulo 1 |
| Wed | 100.0* | Lottery seed |
| Sao Paulo | +2.3 | |
| Independiente Medellin | -4.3 | |
|
| Universidad de Chile 0 Gremio 2 |
| Wed | 100.0* | Lottery seed |
| Gremio | -3.7 | |
| Universidad de Chile | +4.5 | |
|
| Boyaca Chico 2 Aurora 1 |
| Thu | 100.0* | Lottery seed |
| Universidad de Chile | +1.3 | |
| Boyaca Chico | -3.9 | |
| Aurora | +1.7 | |
|
| America de Cali 0 Defensor Sporting 0 |
| Thu | 100.0* | Lottery seed |
| Defensor Sporting | +1.0 | |
| America de Cali | +1.5 | |
|
| Chivas Guadalajara 0 Lanus 0 |
| Tue | 100.0* | Lottery seed |
| Caracas | -0.2 | |
| Chivas Guadalajara | +0.6 | |
| Lanus | +1.3 | |
|
| Palmeiras 1 Sport Recife 1 |
| Wed | 100.0* | Lottery seed |
| Sport Recife | +0.4 | |
| Palmeiras | +0.7 | |
|
| Week of 4/21 |
| Defensor Sporting 4 Independiente Medellin 3 |
| Wed | 100.0* | Lottery seed |
| Sao Paulo | -0.9 | |
| Defensor Sporting | -5.9 | |
| Independiente Medellin | +6.2 | |
|
| Cruzeiro 2 Deportivo Quito 0 |
| Thu | 100.0* | Lottery seed |
| Cruzeiro | -6.0 | |
| Deportivo Quito | +5.2 | |
|
| Sport Recife 2 Colo-Colo 1 |
| Wed | 100.0* | Lottery seed |
| Sport Recife | -5.7 | |
| Colo-Colo | +4.9 | |
|
| Sao Paulo 2 America de Cali 1 |
| Wed | 100.0* | Lottery seed |
| Sao Paulo | -3.2 | |
| Independiente Medellin | +0.7 | |
| America de Cali | +2.4 | |
|
| Deportivo Cuenca 1 Boca Juniors 0 |
| Wed | 100.0* | Lottery seed |
| Boca Juniors | +2.8 | |
| Deportivo Cuenca | -4.5 | |
|
| Nacional-PAR 4 River Plate 2 |
| Thu | 100.0* | Lottery seed |
| Universidad San Martin | -1.0 | |
| River Plate | +3.9 | |
| Nacional-PAR | -2.9 | |
|
| Palmeiras 2 LDU 0 |
| Tue | 100.0* | Lottery seed |
| Palmeiras | -5.0 | |
| LDU | +4.3 | |
|
| Universitario de Sucre 0 Estudiantes 0 |
| Thu | 100.0* | Lottery seed |
| Cruzeiro | +0.5 | |
| Estudiantes | +0.4 | |
| Deportivo Quito | -0.5 | |
| Universitario de Sucre | +1.4 | |
|
| Universidad San Martin 1 Nacional 1 |
| Tue | 100.0* | Lottery seed |
| Nacional | -0.4 | |
| Universidad San Martin | +0.7 | |
|
| Week of 4/28 |
| Colo-Colo 0 Palmeiras 1 |
| Wed | 100.0* | Lottery seed |
| Sport Recife | +0.4 | |
| Palmeiras | -7.5 | |
| Deportivo Quito | -0.2 | |
| Colo-Colo | +7.4 | |
|
| Libertad 0 San Luis 2 |
| Tue | 100.0* | Lottery seed |
| Libertad | +2.5 | |
| San Luis | -4.9 | |
| Universitario | +0.9 | |
|
| Boca Juniors 3 Deportivo Tachira 0 |
| Thu | 100.0* | Lottery seed |
| Boca Juniors | -3.7 | |
| Sao Paulo | +0.4 | |
| Cruzeiro | +0.4 | |
| Sport Recife | +0.4 | |
| Deportivo Cuenca | -0.9 | |
| Deportivo Tachira | +4.4 | |
|
| LDU 2 Sport Recife 3 |
| Wed | 100.0* | Lottery seed |
| Sport Recife | -4.3 | |
| Libertad | +0.6 | |
| San Lorenzo | -0.4 | |
| LDU | +1.8 | |
|
| Aurora 1 Universidad de Chile 2 |
| Tue | 100.0* | Lottery seed |
| Universidad de Chile | -4.4 | |
| Boyaca Chico | +1.4 | |
| Universitario de Sucre | -0.4 | |
| Aurora | +1.1 | |
|
| River Plate 3 Universidad San Martin 0 |
| Thu | 100.0* | Lottery seed |
| Estudiantes | -0.4 | |
| Palmeiras | -0.4 | |
| Universidad de Chile | -0.4 | |
| Chivas Guadalajara | -0.4 | |
| Universidad San Martin | +3.2 | |
| River Plate | -2.2 | |
| San Lorenzo | +0.6 | |
| Lanus | +0.4 | |
|
| San Lorenzo 2 Universitario 0 |
| Tue | 100.0* | Lottery seed |
| Estudiantes | -0.4 | |
| Universitario | +3.5 | |
| San Lorenzo | -2.1 | |
|
| Nacional 3 Nacional-PAR 1 |
| Thu | 100.0* | Lottery seed |
| Nacional | -2.9 | |
| Sao Paulo | +0.6 | |
| Cruzeiro | +0.6 | |
| Sport Recife | +0.6 | |
| Libertad | +0.4 | |
| San Lorenzo | -0.4 | |
| Lanus | -0.6 | |
| Nacional-PAR | +2.2 | |
|
| Everton 1 Chivas Guadalajara 1 |
| Wed | 100.0* | Lottery seed |
| Chivas Guadalajara | -2.5 | |
| Everton | +2.6 | |
| Deportivo Quito | +0.6 | |
|
| Gremio 3 Boyaca Chico 0 |
| Tue | 100.0* | Lottery seed |
| Gremio | -1.5 | |
| Universidad de Chile | -1.0 | |
| Boyaca Chico | +2.7 | |
|
| Guarani 1 Deportivo Cuenca 1 |
| Thu | 100.0* | Lottery seed |
| Boca Juniors | -1.1 | |
| Deportivo Cuenca | +0.5 | |
| Deportivo Tachira | -0.2 | |
| Universitario de Sucre | -0.4 | |
| Guarani | +0.3 | |
|
| Lanus 1 Caracas 1 |
| Wed | 100.0* | Lottery seed |
| Libertad | -0.4 | |
| Caracas | +0.5 | |
| Everton | +0.2 | |
| Lanus | -0.4 | |