| Week of 4/8 |
| Chivas Guadalajara 3 Santos 2 |
| Wed | 100.0* | Lottery seed |
| Cucuta Deportivo | -1.3 | |
| Santos | +6.4 | |
| Chivas Guadalajara | -6.2 | |
|
| Arsenal 2 Fluminense 0 |
| Wed | 100.0* | Lottery seed |
| Fluminense | +3.5 | |
| LDU | -1.1 | |
| Arsenal | -5.5 | |
|
| Audax Italiano 1 Sao Paulo 0 |
| Thu | 100.0* | Lottery seed |
| Sao Paulo | +5.2 | |
| Audax Italiano | -6.6 | |
|
| Libertad 3 LDU 1 |
| Tue | 100.0* | Lottery seed |
| Fluminense | -1.7 | |
| LDU | +3.7 | |
| Libertad | -3.7 | |
|
| Cienciano 0 Flamengo 3 |
| Wed | 100.0* | Lottery seed |
| Flamengo | -5.8 | |
| Nacional | +0.8 | |
| Cienciano | +4.6 | |
|
| Atlas 3 Boca Juniors 1 |
| Wed | 100.0* | Lottery seed |
| Atlas | -4.1 | |
| Boca Juniors | +4.1 | |
|
| Colo-Colo 2 Union Maracaibo 0 |
| Thu | 100.0* | Lottery seed |
| Atlas | +0.4 | |
| Boca Juniors | +0.5 | |
| Colo-Colo | -3.0 | |
| Union Maracaibo | +1.6 | |
|
| Sportivo Luqueno 1 Atletico Nacional 3 |
| Thu | 100.0* | Lottery seed |
| Sao Paulo | +0.3 | |
| Atletico Nacional | -3.1 | |
| Sportivo Luqueno | +2.2 | |
| Audax Italiano | +0.3 | |
|
| San Jose 2 Cucuta Deportivo 4 |
| Tue | 100.0* | Lottery seed |
| Cucuta Deportivo | -0.9 | |
| San Jose | +0.5 | |
|
| Week of 4/15 |
| Universidad Catolica 2 America 0 |
| Thu | 100.0* | Lottery seed |
| River Plate | -1.7 | |
| America | +7.3 | |
| Universidad Catolica | -5.4 | |
| Arsenal | +0.7 | |
|
| Real Potosi 5 Cruzeiro 1 |
| Thu | 100.0* | Lottery seed |
| Cruzeiro | +3.7 | |
| Real Potosi | -4.6 | |
| Deportivo Cuenca | +0.9 | |
| Danubio | +0.7 | |
| San Jose | +0.7 | |
|
| Santos 2 Cucuta Deportivo 1 |
| Wed | 100.0* | Lottery seed |
| Estudiantes | -0.7 | |
| Cucuta Deportivo | +3.2 | |
| Santos | -5.6 | |
| Lanus | +0.7 | |
| Chivas Guadalajara | +1.2 | |
|
| Libertad 1 Arsenal 2 |
| Wed | 100.0* | Lottery seed |
| Arsenal | -4.8 | |
| Danubio | -0.7 | |
| Libertad | +4.0 | |
|
| River Plate 5 Universidad San Martin 0 |
| Thu | 100.0* | Lottery seed |
| River Plate | -4.9 | |
| America | +1.2 | |
| Arsenal | -0.3 | |
| Universidad San Martin | +3.1 | |
|
| San Lorenzo 3 Caracas 0 |
| Thu | 100.0* | Lottery seed |
| San Lorenzo | -5.5 | |
| Caracas | +5.2 | |
|
| Estudiantes 2 Deportivo Cuenca 0 |
| Tue | 100.0* | Lottery seed |
| Estudiantes | -3.9 | |
| Lanus | +0.7 | |
| Deportivo Cuenca | +3.8 | |
|
| Fluminense 1 LDU 0 |
| Thu | 100.0* | Lottery seed |
| Fluminense | -4.0 | |
| Santos | -0.2 | |
| LDU | +4.1 | |
|
| Danubio 1 Lanus 2 |
| Tue | 100.0* | Lottery seed |
| Estudiantes | +0.7 | |
| Lanus | -3.2 | |
| Deportivo Cuenca | +0.5 | |
| Danubio | +2.0 | |
|
| San Jose 0 Chivas Guadalajara 3 |
| Wed | 100.0* | Lottery seed |
| Santos | +0.8 | |
| Chivas Guadalajara | -2.3 | |
| Danubio | -0.4 | |
| San Jose | +1.6 | |
|
| Week of 4/22 |
| Sportivo Luqueno 4 Audax Italiano 1 |
| Wed | 100.0* | Lottery seed |
| Sao Paulo | -2.4 | |
| America | -0.5 | |
| Atletico Nacional | -1.8 | |
| Sportivo Luqueno | -4.5 | |
| Audax Italiano | +6.9 | |
| Real Potosi | +0.8 | |
| Deportivo Cuenca | +0.8 | |
| Universidad San Martin | +0.8 | |
| Danubio | +0.6 | |
|
| Sao Paulo 1 Atletico Nacional 0 |
| Wed | 100.0* | Lottery seed |
| Atlas | -0.2 | |
| Cruzeiro | -0.2 | |
| Estudiantes | -0.2 | |
| Cucuta Deportivo | -0.2 | |
| Sao Paulo | -9.1 | |
| Atletico Nacional | +9.2 | |
| Audax Italiano | +0.7 | |
|
| Flamengo 2 Coronel Bolognesi 0 |
| Wed | 100.0* | Lottery seed |
| Flamengo | -3.7 | |
| River Plate | +0.3 | |
| Nacional | +1.7 | |
| Danubio | -0.2 | |
| San Jose | -0.2 | |
| Libertad | -0.4 | |
| Coronel Bolognesi | +1.1 | |
|
| Nacional 3 Cienciano 1 |
| Wed | 100.0* | Lottery seed |
| Flamengo | +0.4 | |
| Nacional | -4.2 | |
| Arsenal | -0.2 | |
| Cienciano | +2.4 | |
|
| Boca Juniors 3 Union Maracaibo 0 |
| Tue | 100.0* | Lottery seed |
| Boca Juniors | -3.0 | |
| Colo-Colo | +0.8 | |
| Arsenal | +0.4 | |
| Danubio | -0.2 | |
| San Jose | -0.2 | |
| Libertad | -0.2 | |
| Union Maracaibo | +0.8 | |
|
| Colo-Colo 1 Atlas 1 |
| Tue | 100.0* | Lottery seed |
| River Plate | -0.6 | |
| Atlas | -1.6 | |
| Boca Juniors | +0.8 | |
| Colo-Colo | +1.5 | |