| Week of 4/10 |
| Cerro Porteno 1 Deportes Tolima 0 |
| Tue | 100.0* | Lottery seed |
| Deportes Tolima | +4.9 | |
| Cerro Porteno | -5.7 | |
|
| Cucuta Deportivo 3 Gremio 1 |
| Wed | 100.0* | Lottery seed |
| Gremio | +4.7 | |
| Cucuta Deportivo | -4.6 | |
| Deportes Tolima | -0.6 | |
|
| Bolivar 0 Toluca 2 |
| Thu | 100.0* | Lottery seed |
| Toluca | -5.6 | |
| Boca Juniors | +0.6 | |
| Bolivar | +4.4 | |
|
| Real Potosi 3 Parana 1 |
| Tue | 100.0* | Lottery seed |
| Parana | +4.3 | |
| Real Potosi | -5.2 | |
|
| Libertad 1 America 2 |
| Wed | 100.0* | Lottery seed |
| Libertad | +3.2 | |
| America | -5.3 | |
| Banfield | +0.6 | |
|
| Nacional 2 Velez Sarsfield 0 |
| Thu | 100.0* | Lottery seed |
| Velez Sarsfield | +4.8 | |
| Nacional | -5.6 | |
|
| Audax Italiano 2 Necaxa 1 |
| Wed | 100.0* | Lottery seed |
| Necaxa | +4.5 | |
| Audax Italiano | -5.1 | |
|
| Emelec 1 Internacional 2 |
| Tue | 100.0* | Lottery seed |
| Nacional | +0.6 | |
| Internacional | -5.0 | |
| Emelec | +3.8 | |
|
| Week of 4/18 |
| Internacional 1 Nacional 0 |
| Thu | 100.0* | Lottery seed |
| Libertad | -0.4 | |
| Velez Sarsfield | +0.7 | |
| Nacional | +4.8 | |
| Internacional | -6.7 | |
|
| Gimnasia y Esgrima 3 Defensor Sporting 0 |
| Thu | 100.0* | Lottery seed |
| America | -0.4 | |
| Defensor Sporting | +4.4 | |
| Gimnasia y Esgrima | -5.7 | |
| Real Potosi | +0.4 | |
|
| Velez Sarsfield 1 Emelec 0 |
| Thu | 100.0* | Lottery seed |
| Velez Sarsfield | -5.5 | |
| Nacional | +1.6 | |
| Internacional | +1.4 | |
| Emelec | +1.7 | |
|
| America 2 El Nacional 1 |
| Wed | 100.0* | Lottery seed |
| Libertad | +1.6 | |
| America | -5.1 | |
| Banfield | +1.5 | |
| El Nacional | +1.2 | |
|
| Banfield 0 Libertad 1 |
| Wed | 100.0* | Lottery seed |
| Libertad | -5.5 | |
| Banfield | +5.3 | |
|
| Alianza Lima 0 Sao Paulo 1 |
| Wed | 100.0* | Lottery seed |
| Necaxa | +1.4 | |
| Sao Paulo | -4.9 | |
| Audax Italiano | +0.8 | |
| Alianza Lima | +1.5 | |
|
| Parana 2 Union Maracaibo 1 |
| Wed | 100.0* | Lottery seed |
| Parana | -4.7 | |
| Real Potosi | +1.9 | |
| Union Maracaibo | +1.6 | |
|
| Flamengo 1 Real Potosi 0 |
| Wed | 100.0* | Lottery seed |
| Flamengo | -0.8 | |
| Parana | -2.1 | |
| Real Potosi | +4.7 | |
|
| Santos 3 Deportivo Pasto 0 |
| Thu | 100.0* | Lottery seed |
| Santos | -0.4 | |
| Flamengo | +0.4 | |
| Union Maracaibo | -0.4 | |
| El Nacional | -0.4 | |
| Deportivo Pasto | +1.2 | |
|
| Week of 4/24 |
| Gremio 1 Cerro Porteno 0 |
| Tue | 100.0* | Lottery seed |
| Gremio | -8.9 | |
| Cucuta Deportivo | +0.4 | |
| Deportes Tolima | +0.2 | |
| Cerro Porteno | +7.7 | |
|
| Deportes Tolima 3 Cucuta Deportivo 4 |
| Tue | 100.0* | Lottery seed |
| Cucuta Deportivo | -7.8 | |
| Defensor Sporting | +0.2 | |
| Deportes Tolima | +7.4 | |
| Real Potosi | +0.3 | |
|
| Boca Juniors 7 Bolivar 0 |
| Thu | 100.0* | Lottery seed |
| Toluca | +1.9 | |
| Boca Juniors | -7.9 | |
| Cienciano | +1.7 | |
| LDU | +0.4 | |
| River Plate | +0.4 | |
| Real Potosi | -0.4 | |
| Bolivar | +1.1 | |
|
| Necaxa 2 Alianza Lima 0 |
| Wed | 100.0* | Lottery seed |
| Necaxa | -6.1 | |
| Sao Paulo | +2.0 | |
| Audax Italiano | +2.0 | |
| Banfield | +0.4 | |
| Gimnasia y Esgrima | +0.3 | |
| Emelec | -0.3 | |
| Union Maracaibo | -0.4 | |
| El Nacional | -0.4 | |
| Deportivo Pasto | -0.5 | |
| Alianza Lima | +1.6 | |
|
| Toluca 3 Cienciano 0 |
| Thu | 100.0* | Lottery seed |
| Toluca | -7.5 | |
| Necaxa | +0.2 | |
| Velez Sarsfield | +0.2 | |
| Cienciano | +6.8 | |
|
| LDU 3 Caracas 1 |
| Wed | 100.0* | Lottery seed |
| Colo-Colo | -1.7 | |
| Cucuta Deportivo | -0.5 | |
| Parana | -0.5 | |
| Defensor Sporting | -0.5 | |
| Caracas | +4.5 | |
| LDU | -2.8 | |
| Deportes Tolima | +0.6 | |
| Cerro Porteno | +0.6 | |
| Real Potosi | +0.6 | |
|
| River Plate 1 Colo-Colo 0 |
| Wed | 100.0* | Lottery seed |
| Colo-Colo | +3.5 | |
| Caracas | -1.3 | |
| River Plate | -2.8 | |
| Deportes Tolima | +0.6 | |
| Cerro Porteno | +0.6 | |
| Real Potosi | +0.6 | |
|
| Sao Paulo 2 Audax Italiano 2 |
| Wed | 100.0* | Lottery seed |
| Libertad | -0.7 | |
| Necaxa | -0.7 | |
| Sao Paulo | -1.0 | |
| Audax Italiano | +2.6 | |