| Week of 4/26 |
| Independiente Medellin 2 America de Cali 0 |
| Tue | 100.0* | Lottery seed |
| Independiente Medellin | -5.9 | |
| Atletico-PR | -0.2 | |
| America de Cali | +3.6 | |
|
| The Strongest 2 Quilmes 1 |
| Thu | 100.0* | Lottery seed |
| Universidad de Chile | -0.7 | |
| Quilmes | +4.5 | |
| The Strongest | -3.9 | |
|
| Cobreloa 2 San Lorenzo 0 |
| Tue | 100.0* | Lottery seed |
| Once Caldas | +0.8 | |
| Cobreloa | -4.7 | |
| San Lorenzo | +3.5 | |
|
| Cerro Porteno 1 Santo Andre 0 |
| Thu | 100.0* | Lottery seed |
| Cerro Porteno | -2.6 | |
| Santo Andre | +3.3 | |
|
| Sporting Cristal 0 Boca Juniors 3 |
| Wed | 100.0* | Lottery seed |
| Boca Juniors | -3.1 | |
| Sporting Cristal | +2.8 | |
|
| Bolivar 2 LDU 2 |
| Wed | 100.0* | Lottery seed |
| LDU | -0.3 | |
| Danubio | -0.3 | |
| Bolivar | +1.5 | |
|
| Deportivo Cuenca 1 Pachuca 1 |
| Wed | 100.0* | Lottery seed |
| Boca Juniors | -0.3 | |
| Pachuca | +0.8 | |
| Sporting Cristal | -0.3 | |
| Deportivo Cuenca | +0.8 | |
|
| Week of 5/3 |
| Junior Barranquilla 3 Nacional 2 |
| Tue | 100.0* | Lottery seed |
| Junior Barranquilla | -4.9 | |
| Olmedo | +1.4 | |
| Nacional | +3.8 | |
|
| Chivas Guadalajara 3 Cobreloa 1 |
| Thu | 100.0* | Lottery seed |
| Chivas Guadalajara | -5.3 | |
| Once Caldas | +0.9 | |
| Cobreloa | +4.4 | |
|
| Pachuca 2 Sporting Cristal 0 |
| Wed | 100.0* | Lottery seed |
| Pachuca | -5.0 | |
| Olmedo | -0.3 | |
| Sporting Cristal | +4.6 | |
|
| San Lorenzo 0 Once Caldas 1 |
| Thu | 100.0* | Lottery seed |
| Chivas Guadalajara | +1.1 | |
| Once Caldas | -3.7 | |
| Cobreloa | +0.9 | |
| Caracas | -0.4 | |
| San Lorenzo | +1.6 | |
|
| Banfield 3 Caracas 1 |
| Tue | 100.0* | Lottery seed |
| Banfield | -2.9 | |
| Caracas | +2.9 | |
|
| Deportivo Tachira 1 Palmeiras 2 |
| Wed | 100.0* | Lottery seed |
| Palmeiras | -2.8 | |
| Santo Andre | +0.5 | |
| Deportivo Tachira | +1.8 | |
|
| Boca Juniors 3 Deportivo Cuenca 0 |
| Wed | 100.0* | Lottery seed |
| Boca Juniors | -1.4 | |
| Caracas | -0.4 | |
| Deportivo Cuenca | +1.5 | |
|
| River Plate 1 Olmedo 1 |
| Tue | 100.0* | Lottery seed |
| Junior Barranquilla | +0.8 | |
| Olmedo | -2.4 | |
| Nacional | +0.8 | |
|
| Tigres UANL 0 Alianza Lima 0 |
| Tue | 100.0* | Lottery seed |
| Tigres UANL | +0.7 | |
| Alianza Lima | -0.8 | |
|
| Week of 5/10 |
| America de Cali 0 Libertad 1 |
| Tue | 100.0* | Lottery seed |
| Independiente Medellin | -0.6 | |
| Atletico-PR | -2.0 | |
| America de Cali | +5.7 | |
| Libertad | -3.7 | |
| Alianza Lima | +0.8 | |
| Caracas | +0.5 | |
| San Lorenzo | +0.5 | |
|
| Atletico-PR 0 Independiente Medellin 4 |
| Tue | 100.0* | Lottery seed |
| Independiente Medellin | -6.5 | |
| Atletico-PR | +6.5 | |
| America de Cali | -0.2 | |
| Cobreloa | +0.3 | |
|
| Santos 6 Bolivar 0 |
| Wed | 100.0* | Lottery seed |
| Santos | -4.6 | |
| LDU | -0.6 | |
| Bolivar | +5.3 | |
|
| Sao Paulo 3 The Strongest 0 |
| Wed | 100.0* | Lottery seed |
| Sao Paulo | -2.9 | |
| Universidad de Chile | +0.6 | |
| Olmedo | -0.2 | |
| Sporting Cristal | -0.2 | |
| Libertad | -0.5 | |
| The Strongest | +2.6 | |
|
| Santo Andre 6 Deportivo Tachira 0 |
| Thu | 100.0* | Lottery seed |
| Santo Andre | -3.2 | |
| Danubio | +0.5 | |
| Olmedo | +0.5 | |
| Sporting Cristal | +0.5 | |
| Bolivar | +0.5 | |
| Caracas | -0.2 | |
| San Lorenzo | -0.5 | |
| Nacional | -0.5 | |
| Deportivo Cuenca | -0.5 | |
| Deportivo Tachira | +2.2 | |
|
| LDU 1 Danubio 1 |
| Wed | 100.0* | Lottery seed |
| Santos | -0.7 | |
| Atletico-PR | -0.3 | |
| Once Caldas | -0.7 | |
| LDU | +0.0 | |
| Danubio | +2.6 | |
| Olmedo | +0.7 | |
|
| Quilmes 1 Universidad de Chile 1 |
| Wed | 100.0* | Lottery seed |
| Sao Paulo | -0.5 | |
| Universidad de Chile | +1.8 | |
| Sporting Cristal | -0.3 | |
| Libertad | -0.3 | |
| Quilmes | +0.6 | |
| Alianza Lima | +0.4 | |
|
| Palmeiras 0 Cerro Porteno 0 |
| Thu | 100.0* | Lottery seed |
| Boca Juniors | -0.4 | |
| Santos | -0.4 | |
| Tigres UANL | -0.4 | |
| Sao Paulo | -0.4 | |
| Cerro Porteno | +1.2 | |
| Pachuca | -0.3 | |
| Atletico-PR | -0.3 | |
| Palmeiras | -0.6 | |
| Once Caldas | +0.4 | |
| Universidad de Chile | +0.4 | |
| Junior Barranquilla | +0.4 | |
| Santo Andre | +0.4 | |